can I take Wellbutrin, Alprazolam and Fioricet at the same time? Or if not all at the same time, I usually take the Wellbutrin every A.M., the Alprazolam when needed for anxiety and the Fioricet as needed. Is this safe? Best answer: Answer by S Yes that’s perfectly fine. In the future, call a pharmacist… Continue reading can I take Wellbutrin, Alprazolam and Fioricet at the same time?