Gabapentin mechanism of action

Gabapentin was designed to mimic the neurotransmitter GABA. It does not, however, bind to GABA receptors. Its mechanism of action as an antiepileptic agent likely involves its inhibition of the alpha 2-delta subunit of voltage-gated calcium channels . It was first approved as an anticonvulsant…

Gabapentin Drug Interaction

Gabapentin Drug Interaction   Alcohol (Ethyl): CNS Depressants may enhance the CNS depressant effect of Alcohol (Ethyl). Monitor therapy Alizapride: May enhance the CNS depressant effect of CNS Depressants. Monitor therapy Aluminum Hydroxide: May decrease the serum concentration of Gabapentin. Management: Administer…

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Gabapentin is structurally related to GABA. However, it does not bind to GABAA or GABAB receptors, and it does not appear to influence synthesis or uptake of GABA. High affinity gabapentin binding sites have been located throughout the brain; these sites correspond…

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How Gabapentin works

Gabapentin is a medicine that may be used for the treatment of certain seizure disorders or nerve pain. Gabapentin is a structural analogue of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) that was first approved for use in the United States…

Gabapentin Warnings

Gabapentin, a prescription medication primarily used to treat seizures and neuropathic pain associated with herpes zoster, or shingles, is showing up in more drug overdoses. It’s a trend that’s worrying doctors and lawmakers. Since the drug was first approved for…